Dental Implants Research Today is a free monthly online journal that collates and summarizes the latest research about Dental Implants, including details on dentistry, surgery, tooth implants.

Zirconium oxide regulates RNA interfering of osteoblast-like cells.

Palmieri A, Pezzetti F, Brunelli G, Zollino I, Lo Muzio L, Martinelli M, Scapoli L, Arlotti M, Masiero E, Carinci F

Institute of Histology, University of Bologna and Center of Molecular Genetics, CARISBO Foundation, Bologna, Italy.

Zirconium oxide (ZO) has outstanding mechanical properties, high biocompatibility and high resistance to scratching. Since dental implants are made with ZO and the genetic effects of ZO on osteoblasts are incompletely understood, we used microRNA microarray techniques to investigate the translation process in osteoblasts exposed to ZO. By using miRNA microarrays containing 329 probes designed from Human miRNA sequences, we identified in osteoblast-like cells line (MG-63) cultured on ZO disks several miRNA whose expression was significantly modified. The most notable regulated genes acting on osteoblasts are: NOG, SHOX, IGF1, BMP1 and FGFR1. The data reported below represent the first study on translation regulation in osteoblasts exposed to zirconium and one in which the effect of ZO on bone formation has been detected.

Published 1 April 2008 in J Mater Sci Mater Med, 19(6): 2471-6.
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